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GHK-Cu is a naturally occurring copper-peptide complex consisting of the tripeptide glycyl-L-histidyl-L-lysine chelated with a divalent copper ion. As an endogenous signalling molecule involved in metal ion transport and cellular regulation, it occupies a distinctive position in peptide research — functioning through both peptide-mediated interactions and copper-dependent biochemical activity simultaneously.
Copper is an essential trace element required by numerous enzymatic and structural proteins involved in redox balance, extracellular matrix organisation, and cellular metabolism. By acting as a carrier and regulator of bioavailable copper, GHK-Cu is studied for its role in maintaining metal homeostasis and influencing downstream pathways linked to cellular growth, differentiation, and tissue remodelling. In preclinical research models, exposure has been associated with altered gene expression patterns and modulation of signalling pathways related to extracellular matrix dynamics, oxidative stress response, and cellular turnover.
A note on appearance: The distinctive blue colouration of GHK-Cu is a direct result of the copper coordination complex and is an expected characteristic of the compound. This does not indicate a quality or purity issue.
Research Applications
GHK-Cu is employed as a molecular probe across a range of biochemistry and cellular biology research contexts, including studies into copper transport, binding, and homeostasis, copper-dependent signalling pathways involved in cellular growth and differentiation, gene expression changes in redox-sensitive and extracellular matrix-related signalling, and peptide-metal interactions in both in vitro and ex vivo experimental models. Observed effects are context-dependent and vary with concentration, exposure duration, and experimental system.
Reconstitution
Reconstitute in sterile water or a suitable buffered aqueous solution under dry, inert conditions — avoid moisture uptake during handling. Importantly, avoid metal-chelating agents such as EDTA or buffers that may disrupt copper coordination, as this will compromise the integrity of the compound. Mix gently and filter sterilise through a 0.22 µm membrane if required prior to use. Monitor for precipitation or pH shifts before use in sensitive assays. Once reconstituted, aliquot into single-use volumes and store at −20°C or below. Light exposure and prolonged aqueous storage may reduce stability, so protect solutions accordingly.
Important Notice
All products supplied by Perfect Profile Peptides are intended strictly for in vitro and laboratory research use only. They are not suitable for human or veterinary administration and should be handled in accordance with standard laboratory safety protocols.
GHK-Cu is a naturally occurring copper-peptide complex consisting of the tripeptide glycyl-L-histidyl-L-lysine chelated with a divalent copper ion. As an endogenous signalling molecule involved in metal ion transport and cellular regulation, it occupies a distinctive position in peptide research — functioning through both peptide-mediated interactions and copper-dependent biochemical activity simultaneously.
Copper is an essential trace element required by numerous enzymatic and structural proteins involved in redox balance, extracellular matrix organisation, and cellular metabolism. By acting as a carrier and regulator of bioavailable copper, GHK-Cu is studied for its role in maintaining metal homeostasis and influencing downstream pathways linked to cellular growth, differentiation, and tissue remodelling. In preclinical research models, exposure has been associated with altered gene expression patterns and modulation of signalling pathways related to extracellular matrix dynamics, oxidative stress response, and cellular turnover.
A note on appearance: The distinctive blue colouration of GHK-Cu is a direct result of the copper coordination complex and is an expected characteristic of the compound. This does not indicate a quality or purity issue.
Research Applications
GHK-Cu is employed as a molecular probe across a range of biochemistry and cellular biology research contexts, including studies into copper transport, binding, and homeostasis, copper-dependent signalling pathways involved in cellular growth and differentiation, gene expression changes in redox-sensitive and extracellular matrix-related signalling, and peptide-metal interactions in both in vitro and ex vivo experimental models. Observed effects are context-dependent and vary with concentration, exposure duration, and experimental system.
Reconstitution
Reconstitute in sterile water or a suitable buffered aqueous solution under dry, inert conditions — avoid moisture uptake during handling. Importantly, avoid metal-chelating agents such as EDTA or buffers that may disrupt copper coordination, as this will compromise the integrity of the compound. Mix gently and filter sterilise through a 0.22 µm membrane if required prior to use. Monitor for precipitation or pH shifts before use in sensitive assays. Once reconstituted, aliquot into single-use volumes and store at −20°C or below. Light exposure and prolonged aqueous storage may reduce stability, so protect solutions accordingly.
Important Notice
All products supplied by Perfect Profile Peptides are intended strictly for in vitro and laboratory research use only. They are not suitable for human or veterinary administration and should be handled in accordance with standard laboratory safety protocols.