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MOTS-c (Mitochondrial ORF of the Twelve S rRNA-c) | Research Peptide
MOTS-c is a synthetic peptide corresponding to a naturally occurring mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA region. As a mitochondrial-derived regulatory peptide, it represents a relatively recently identified class of signalling molecules and is used in experimental research to investigate the intersection of mitochondrial function, metabolic regulation, and nuclear-mitochondrial communication pathways.
In biochemical and cellular research systems, MOTS-c has been shown to influence intracellular signalling pathways associated with energy sensing, insulin signalling, and cellular stress responses. Experimental models commonly examine its effects on AMPK activation, metabolic gene expression, and adaptive stress signalling cascades. Observed molecular responses are dependent on concentration, exposure duration, cell type, and metabolic state of the model system.
Research Applications
MOTS-c is employed as a molecular probe across a range of metabolism and mitochondrial biology research contexts, including studies into mitochondrial-derived peptide signalling, metabolic regulation and energy homeostasis pathways, AMPK activation dynamics, and nuclear-mitochondrial communication. It is also used as a reference compound in investigations examining adaptive stress responses and metabolic gene expression. As with all research peptides, observed responses are dependent on experimental design, model system, and peptide concentration.
Reconstitution
Reconstitute in sterile water or a suitable buffered aqueous solution under dry conditions — the peptide is hygroscopic and should be handled accordingly. Mix gently and avoid vigorous agitation. Filter sterilise through a 0.22 µm membrane if required prior to use. Once reconstituted, aliquot into single-use volumes and store at −20°C or below. Avoid repeated freeze-thaw cycles to preserve peptide integrity.
Important Notice
All products supplied by Perfect Profile Peptides are intended strictly for in vitro and laboratory research use only. They are not suitable for human or veterinary administration and should be handled in accordance with standard laboratory safety protocols.
MOTS-c (Mitochondrial ORF of the Twelve S rRNA-c) | Research Peptide
MOTS-c is a synthetic peptide corresponding to a naturally occurring mitochondrial-derived peptide encoded within the mitochondrial 12S rRNA region. As a mitochondrial-derived regulatory peptide, it represents a relatively recently identified class of signalling molecules and is used in experimental research to investigate the intersection of mitochondrial function, metabolic regulation, and nuclear-mitochondrial communication pathways.
In biochemical and cellular research systems, MOTS-c has been shown to influence intracellular signalling pathways associated with energy sensing, insulin signalling, and cellular stress responses. Experimental models commonly examine its effects on AMPK activation, metabolic gene expression, and adaptive stress signalling cascades. Observed molecular responses are dependent on concentration, exposure duration, cell type, and metabolic state of the model system.
Research Applications
MOTS-c is employed as a molecular probe across a range of metabolism and mitochondrial biology research contexts, including studies into mitochondrial-derived peptide signalling, metabolic regulation and energy homeostasis pathways, AMPK activation dynamics, and nuclear-mitochondrial communication. It is also used as a reference compound in investigations examining adaptive stress responses and metabolic gene expression. As with all research peptides, observed responses are dependent on experimental design, model system, and peptide concentration.
Reconstitution
Reconstitute in sterile water or a suitable buffered aqueous solution under dry conditions — the peptide is hygroscopic and should be handled accordingly. Mix gently and avoid vigorous agitation. Filter sterilise through a 0.22 µm membrane if required prior to use. Once reconstituted, aliquot into single-use volumes and store at −20°C or below. Avoid repeated freeze-thaw cycles to preserve peptide integrity.
Important Notice
All products supplied by Perfect Profile Peptides are intended strictly for in vitro and laboratory research use only. They are not suitable for human or veterinary administration and should be handled in accordance with standard laboratory safety protocols.